Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Treatment for chloroquine itching Long term plaquenil use and electrolyte imbalance In simplest terms, ANA-negative lupus is a condition in which a person’s ANA—or antinuclear antibody—test comes back negative, but the person exhibits traits consistent with someone diagnosed with lupus. The ANA test is used to screen for lupus, not diagnose it. Antinuclear antibody ANA test. A positive test for the presence of these antibodies — produced by your immune system — indicates a stimulated immune system. While most people with lupus have a positive ANA test, most people with a positive ANA do not have lupus. If you test positive for ANA, your doctor may advise more-specific antibody testing. Vanessa, whatever you decide is the best for you is key and how you feel in yourself, give the plaquenil a bit longer if you are not reacting as it does take a while to get into the system but if you are unhappy about it, discuss the concerns you have with the doctor and take it from there. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Ana and plaquenil PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Lupus - Diagnosis and treatment - Mayo Clinic Plaquenil retinal screening guidelines after stoppingPlaquenil and lower back painChloroquine phosphate syrupPlaquenil pictures3-hydroxychloroquine Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. How is plaquenil hydroxychloroquine used to treat lupus?. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. For this reason, you can think of antimalarials as a sort of “lupus life insurance.” Yes I have had a positive Ana test in 2003 0 and just this year had two negative Ana, one while on plaquenil and one after being off plaquenil for 3weeks. Maybe if you are on medication that is what is causing the ana to be negative. Dec 27, 2010 My ANA was high when I was first found to have Vasculitis in April 09, iwth a CRP of over 25. II then went on to have Pleuritis, Pericarditis, more legs issues with rashes, severe photosensitivity, Raynauds, weight loss, fatique, hair loss, etc. But have been on Medrol, Plaquenil, and only a short time of Cellcept.