However, during the treatment of patients with malaria who also had lupus, it was noted that their skin rashes improved. After these drugs were abandoned for the treatment of malaria, more study was done, and they were found to be effective for discoid lupus, subacute cutaneous lupus, dermatomyositis, rheumatoid arthritis, and psoriatic arthritis. Cat's claw and hydroxychloroquine Chloroquine african Lysosomotropic agent chloroquine which Plaquenil pulmonary sarcoidosis Granuloma annulare is a chronic degenerative skin disorder. The most common form is localized granuloma annulare, which is characterized by the presence of small, firm red or yellow colored bumps nodules or papules that appear arranged in a ring on the skin. Perforating granuloma annulare GA is a rare subset of GA with an unknown etiology and chronic course. It occurs most frequently in childhood and it appears as umbilicated papules that involve, most commonly, the extremities. Treatment could be difficult and unsatisfactory. Granuloma annulare GA and necrobiosis lipoidica NL are granulomatous diseases of undetermined etiology. Rarely, both dermatoses have been reported to occur concomitantly in patients. GA and NL are characterized histologically by areas of necrobiosis of collagen. When the drugs were first used, the dosages were generally higher than prescribed today, and a peculiar side-effect on the retina of the eye occurred that permanently affected vision. Plaquenil has a better safety profile than chloroquine and is most commonly used today. Plaquenil granuloma annulare A retrospective analysis of 44 patients with granuloma., Perforating Granuloma Annulare — An Unusual Subtype of a. Antimalarial drugs chloroquineAralen rheumatoid arthritisPlaquenil and lower back painMctd and plaquenil Granuloma annulare GA is a disease characterized by granulomatous inflammation of the dermis. A variant form of the disease, generalized granuloma annulare GGA, can be observed in 15% of affected patients. Localized GA is likely to resolve spontaneously within months or a few years, whereas GGA can persist for decades. Generalized Granuloma Annulare Treated with Monthly.. Granuloma annulare and necrobiosis lipoidica with.. Granuloma Annulare Skin and nails Forums Patient. Dermatology. 2005;2112167-8. Treatment of generalized granuloma annulare with hydroxychloroquine. Cannistraci C, Lesnoni La Parola I, Falchi M, Picardo M. Diagnosis and Management of Granuloma Annulare PEGGY R. CYR, M. D. Maine Medical Center, Portland, Maine G ranuloma annulare is a benign skin condition that typically con-sists of grouped papules. I have been taking plaquenil for one month to treat granuloma annulare and this conditions has worsened since beginnning treatment. Is this to be expected? Is there perhaps a better treatment option I should be looking at. I have a severe case and cosmetically it is very offensive.