It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. I had almost (but not quite) forgotten what these aches and pains feel like, but they're back…I am re-acquainting myself with those symptoms that it tames: the overall flu-like and feverish feeling -- aka malaise -- and joint pain." (Click here to read more). I had a similar experience when I stopped taking plaquenil. Chloroquine 250 mg Plaquenil and muscle stiffness Chloroquine in lactation Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone. Immunosuppressants leflunomide and hydroxychloroquine both have the ability to reduce B-cell activity in Sjögren’s syndrome patients. But clinical trials with these agents alone have failed to show a reduction in disease activity and improvements in other clinical parameters. My joint and muscle pain went up and my energy levels went down. No, but it did alleviate some of the symptoms and improve my quality of life. It was one of those situations where I didn't realize the medication was having such an impact until I stopped it. Hydroxychloroquine for sjogren's syndrome vs another drug Clinical Efficacy of Leflunomide/Hydroxychloroquine., Mycophenolate mofetil with Plaquenil Mayo Clinic Connect Hydroxychloroquine effects on kidneysPlaquenil versus hydroxychloroquine Rated Hydroxychloroquine for Sjogren's Syndrome Report. THIS MEDICINE CAUSES BAD BRAIN FOG,BAD HEADACHES,SHOULD BE TAKING OFF THE MARKET ASAP Hydroxychloroquine Reviews Everyday Health. Leflunomide-Hydroxychloroquine Combo Shows Potential for.. Conquering Sjogren's. Sjogren’s syndrome can affect all moisture-producing glands and tissues in the body – not just the eyes and mouth – and cause a host of symptoms. Below is head-to-toe a look at over-the-counter and prescription treatment options, as well as some medical procedures, for this common autoimmune condition that affects nine times as many women. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription.