It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Who makes generic plaquenil Plaquenil prevents lupus anticoagulangpt antibodies Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Around the third week, muscle weakness in legs and hair loss. Now after 4 1/2 weeks. Druginformer Identified Side Effects Headache, Hypersensitivity, Diarrhoea, Muscular weakness I've been having muscle weakness in my arms, legs, hands and feet for some time now, along with stabbing pains, numbness, burning and tingling and the feeling of cold water hitting my skin. I also have a very uncomfortable tickling feeling in those same body parts as well. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Forgot plaquenil muscle weakness Plaquenil vs. Aralen Prescription Treatment for Malaria Differences., Hydroxychloroquine Sulfate Muscular Weakness Reports. Plaquenil side effects dizziness Muscle weakness out of the blue is definitely worth mentioning to your doctor. It could be overexertion or something else that needs looking into. That said, I have a lot of weakness in my legs as well. It gets worse when I overdo myself. Heck, I have overall weakness when I overdo myself. Hopefully if you rest as much as you can it'll get better. Leg weakness? - Sjogren's World. Muscle weakness and heaviness with sjogrens.. Confirmed Plaquenil Muscle Toxicity - Scleroderma - Inspire. I've been taking Plaquenil 400 mg for nearly 6 mos. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes.