Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have been applied to date. The purpose of the present study is to examine dose equivalence of antidepressants by a less arbitrary and more systematic method. We used data from all randomized, double-blind, flexible-dose trials comparing fluoxetine or paroxetine as standard drugs with any other active antidepressants as monotherapy in the acute phase treatment of unipolar depression. We calculated the ratio of the mean doses for each study and weighted it by the total sample size to find the weighted mean ratio for each drug, which was then used to define the drug׳s dosage equivalent to fluoxetine 40 mg/d. In the primary analysis, fluoxetine 40 mg/day was equivalent to paroxetine dosage of 34.0 mg/day, agomelatine 53.2 mg/day, amitriptyline, 122.3 mg/day, bupropion 348.5 mg/day, clomipramine 116.1 mg/day, desipramine 196.3 mg/day, dothiepin 154.8 mg/day, doxepin 140.1 mg/day, escitalopram 18.0 mg/day, fluvoxamine 143.3 mg/day, imipramine 137.2 mg/day, lofepramine 250.2 mg/day, maprotiline 118.0 mg/day, mianserin, 101.1 mg/day, mirtazapine 50.9 mg/day, moclobemide 575.2 mg/day, nefazodone 535.2 mg/day, nortriptyline 100.9 mg/day, reboxetine 11.5 mg/day, sertraline 98.5 mg/day, trazodone 401.4 mg/day, and venlafaxine 149.4 mg/day. Sensitivity analyses corroborated the results except for doxepin. Depressive disorders are characterized by persistent feelings of sadness and worthlessness and a lack of desire to engage in formerly pleasurable activities. Depression is not a passing blue mood, which almost everyone experiences from time to time, but a complex mind/body illness that interferes with everyday functioning. It not only darkens one's outlook, it is commonly marked by sleep problems and changes in energy levels and appetite. It alters the structure and function of nerve cells so that it disrupts the way the brain processes information and interprets experience. Despite feelings of hopelessness and worthlessness, depression is a treatable condition. It can be treated with psychotherapy or medication, or a combination of both. According to the National Institutes of Health, each year more than 16 million adults in the United States experience at least one episode of major depression. The likelihood that a person will develop depression at some point in life is approximately 10 percent. Azithromycin 250 mg dosage Doxycycline in dogs side effects Information about the prescription drugs manufactured by Camber Pharmaceuticals Inc Drug Interactions. Phenytoin is extensively bound to serum plasma proteins and is prone to competitive displacement. Phenytoin is metabolized by hepatic cytochrome CYP P450 enzymes CYP2C9 and CYP2C19 and is particularly susceptible to inhibitory drug interactions because it A depressive disorder is an illness that involves the body, mood, and thoughts. It interferes with daily life, normal functioning, and causes pain for both the person with the disorder and those. They are different drugs for different purposes, so I am not sure what you are asking. The prescribing physician and dispensing pharmacists should be your first source of information, and if this is not being prescribed, then you should be getting help for your opioid problem. Norco (hydrocodone and acetaminophen) 10 mg is hydrocodone and is for ACUTE pain&lasst 3-4 h, and Opana 40 mg ER is meant for CHRONIC pain and lasts 12 h. Read more Percocet is oxycodone, while Norco (hydrocodone and acetaminophen) is hydrocodone. They are both pain medications for moderate to severe pain. In terms of potency the 2 preparations are about equal. Read more See 1 more doctor answer prescribed you both drugs, I am not sure why you are not asking the prescribing physician and/or the pharmacist who is dispensing the drug. However some patients may do better with one of the preparations. If 2 doctors are prescribing, and one doesn't know about the other, that is a problem. If neither is prescribed, YOU SHOULD NOT be taking these meds. These highlights do not include all the information needed to use ZOLOFT safely and effectively. ZOLOFT (sertraline hydrochloride) tablets, for oral use ZOLOFT (sertraline hydrochloride) oral solution Initial U. Approval: 1991Most common adverse reactions (≥5% and twice placebo) in pooled placebo-controlled MDD, OCD, PD, PTSD, SAD and PMDD clinical trials were nausea, diarrhea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure, and decreased libido (6.1) Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage. For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. Given the 24-hour elimination half-life of ZOLOFT, the recommended interval between dose changes is one week. The recommended starting ZOLOFT dosage in adult women with PMDD is 50 mg per day. ZOLOFT may be administered either continuously (every day throughout the menstrual cycle) or intermittently (only during the luteal phase of the menstrual cycle, i.e., starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). Sertraline strengths Zoloft; INN sertraline, Epanutin 30mg/5ml oral Suspension - Summary of Product. Clomid and tamoxifen View drug images for SERTRALINE HCL. Multiple images may be displayed for medicines available in different strengths, sold under different brand names. SERTRALINE HCL Pictures & Common Dosing ScriptSave WellRx. Depressive Disorders Psychology Today. Lexapro vs Zoloft Main Differences and Similarities - SingleCare. Dose equivalents of antidepressants Evidence-based recommendations from randomized controlled trials These highlights do not include all the information needed to use ZOLOFT safely and effectively. See full prescribing information for ZOLOFT. ZOLOFT sertraline hydrochloride tablets, for oral use Sertraline is indicated for the treatment of Major depressive episodes. Prevention of recurrence of major depressive episodes. Panic disorder, with or without.