The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. Ciprofloxacin iv Ciprofloxacin and alcohol Pfizer's patent on sildenafil citrate expired in some member countries of the EU, Austria, Denmark, France, Germany, Ireland, Italy, The Netherlands, Spain, Sweden, the United Kingdom and Switzerland on 21 June 2013. Sildenafil Citrate, Tablet, 100.0 mg, Oral, Jubilant Generics Limited, Not applicable. Sildenafil Citrate, Tablet, film coated, 50 mg/1, Oral, Unit Dose Services. Pictures of Viagra Sildenafil Citrate, drug imprint information, side effects for the patient. It is a medication that is also called Viagra, Revatio and (in the Indian subcontinent) Caverta. Sildenafil was patented in 1996 and first made to sell in 1998. Sildenafil mostly works in the penis and in the lungs. This helps the penis become erect during sexual intercourse. Because this medicine makes the blood vessels wider, it makes it easier for blood to flow. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a drug used to block the degradative action of c GMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. These drugs are used in the treatment of erectile dysfunction and were the first effective oral treatment available for the condition. Because PDE5 is also present in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been explored for the treatment of pulmonary hypertension. Sildenafil and tadalafil are also indicated for the treatment of pulmonary hypertension. Sildenafil, the prototypical PDE5 inhibitor, was originally discovered during the search of a novel treatment for angina. Studies in 2002 explored its potential for increasing neurogenesis after stroke. PDE5 inhibitors are contraindicated in those taking nitrate medications, such as isosorbide mononitrate or isosorbide dinitrate. Sildenafil citrate wiki Order viagra generic 100 mg 50 mg 25 mg, Sildenafil DB00203 - Sildenafil - DrugBank Doxycycline urinary Sildenafil Citrate, more commonly known as Viagra, is a drug that is used to treat erectile dysfunction and pulmonary arterial hypertension PAH. The main function of the drug is to inhibit the enzyme that degrades cGMP, a regulator of blood flow to the penis. Structural Biochemistry/Viagra Sildenafil Citrate - Wikibooks. Viagra Sildenafil Citrate Patient Information Side Effects and Drug.. Силденафил — Википедия. Vardenafil's indications and contraindications are the same as with other PDE 5 inhibitors; it is closely related in function to sildenafil citrate Viagra and. Sildenafil citrate C28H38N6O11S CID 135413523 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Herbal viagra is a name that can be given to any herbal product advertised as treating erectile. The name "herbal viagra" is taken from the brand name Viagra, under which drug company Pfizer sells sildenafil citrate, a drug that is used to treat.