Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil myalgias Plaquenil prototype My rheumy has officially decided today this is seronegative RA, and its time to start DMARDS to protect my joints. He's giving me a few weeks to do my homework though so that we can choose a medication for this. Basically he wants me to get through the holidays without medication symptoms. He wants me to look at plaquenil and methotrexate. I have had RA for 10 years and have been on Plaquenil pretty much the whole time. Methotrexate did not work for me and made me very nauseous. I also take 5-10 mg prednisone and an injection of Humira every week. I have had no side effects from the Plaquenil. Prednisone is a mean drug however, I can tell you this as a nurse too but I have to. Hydroxychloroquine and sulfasalazine are used for mild. The goal is to minimize both rheumatoid arthritis disease activity and medication side effects. It often takes more than one DMARD to get. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate and plaquenil for ra Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center, Plaquenil for RA?" Rheumatoid Arthritis Community - Support Group Does hydroxychloroquine suppress your immune system Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate vs plaquenil side effects long term and short term. DMARDs for Treating Rheumatoid Arthritis. Arthritis Which would you pick and why? - Plaquenil or.. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Rheumatoid arthritis RA, the most common form of inflammatory arthritis, can lead to significant pain, disability, and deformity, and is a multisystem autoimmune disorder. The hallmark of this disease, erosive joint destruction, results from unchecked synovial inflammation, which can damage articular cartilage and bone, with resultant loss of. Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will.