Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Effects of plaquenil on eyes How can plaquenil affect your eyes Plaquenil and hunger If it made your psoriasis worse, did your psoriasis get back to its pre-Plaquenil state after you stopped the Plaquenil? I'm considering Plaquenil for my next drug to try. I have PsA but also have Sjogren's Syndrome, and Plaquenil works well for many with Sjogren's Syndrome. Before using Plaquenil, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase G-6-PD deficiency. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. I, too, have PSA and the spondylitis type. I am currently on Plaquenil for the PSA as it works for my fingers and have been on Sulfasalazine for three weeks and am up to the 2 pills twice a day for the last few days for my SI joint. I work full time and try to get up and walk around or do something physical at least every two hours or I lock up and its ridiculous. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Can plaquenil cause psoriasis Psoriasis Causes & Triggers National Psoriasis Foundation, Plaquenil Uses, Dosage & Side Effects - Synthesis of chloroquine phosphate pptUse of plaquenil for osteoarthritisChloroquine as antiamoebic Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil and Psoriatic Arthritis - Reviews. Can Psoriasis Cause Nail Problems?. Patients who are genetically deficient in a certain enzyme, called G6PD, can develop a severe anemia resulting from the rupture of red blood cells. This enzyme deficiency is more common in persons of African descent and can be evaluated by blood testing. Hydroxychloroquine may worsen psoriasis. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Psoriasis and lupus are both autoimmune disorders. They have some symptoms in common, but these conditions are very different. Learn more about each condition and how to tell the difference.