It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Maximum dose of plaquenil Chloroquine retinopathy Biliary cirrhosis primary is found among people who take Plaquenil, especially for people who are female, 60+ old, also take medication Nexium, and have Gastroesophageal reflux disease Plaquenil can damage the retina of the eye. This can lead to blindness. This problem is most common when high doses are taken for a long time. If you will be taking Plaquenil for a while, it is recommended to have a thorough eye exam before starting it and every three months while taking it. Aug 22, 2011 Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and cirrhosis Cirrhosis of the liver Life expectancy and stages, Plaquenil Warnings and Precautions Plaquenil cause itchingChloroquine dosing for ophthalmologyBenadryl and plaquenilHydroxychloroquine doesPlaquenil for polymyalgia rheumatica Make sure you tell your doctor if you have any other medical problems, especially Allergy to 4-aminoquinoline compounds eg, chloroquine—Should not be used in patients with this condition. Blood or bone marrow problems or. Diabetes or. Eye or vision problems or. Muscle problems or. Nerve problems or. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Plaquenil and elevated liver enzymes?. What Is Cirrhosis of the Liver? Symptoms,Treatment, Causes.. I can't begin to tell you how people react when you say you have cirrhosis. It is very hard. I also now have stage one kidney disease. At the time of diagnosis, I was put on 30 mg of Prednisone daily, and two months later 400 mg of Plaquenil was added. For the first four months, everything was wonderful. In patients with CLD, ofloxacin has been used safely as a substitute for rifampicin and may be less hepatotoxic when combined with pyrazinmide compared with rifampin and pyrazinamide. 152 INH has an increased risk of DILI, especially in slow acetylators slow inactivators among other genetic polymorphisms, attributed to increased blood levels in cirrhosis. 153, 154 An excess incidence of elevated LFTs has been recorded in patients with hepatitis B and hepatitis C, 155, 156 and while it is. In a healthy liver, this scar tissue breaks down after the liver has regenerated new cells 3. in a diseased liver, scar tissue formation outpaces liver cell regeneration 4. in a diseased liver, hepatic stellate cells remain activated leading to a build-up of collagen 5.