Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine resistance testing Chloroquine classification I believe this has been mentioned a while back, but thought I'd ask again who has gotten small brown spots on their skin after sun exposure? I've been on Plaquenil about 2 months, and it has helped my knee/back pain, which is wonderful! I also had read that th Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram A known side effect of using antimalarials long term is dark patches on the skin. The Lupus Encyclopedia Thomas Jr. 2014 says this 'One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil side effects skin discoloration Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Will you have Skin hyperpigmentation with Plaquenil. Plaquenil and dental extractionsLowest prices for hydroxychloroquinePlaquenil and joint replaHydroxychloroquine teratogenic effects Nov 23, 2009 We attribute this to both Plaquenil and Pilates, the latter of which I have now been doing weekly all year, and I also do some of the exercises daily if I find I have joint pain. It always helps. The little while circles on my skin are the only side effect of Plaquenil that I know of. Plaquenil and 'white patches' on my skin? - Inspire. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Hydroxychloroquine Plaquenil Success, Reviews and Side.. I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.