Dementia is found among people who take Tamoxifen citrate, especially for people who are female, 60 old , have been taking the drug for 2 - 5 years, also take medication Aspirin, and have High blood pressure. This study is created by e Health Me based on reports of 9,041 people who have side effects when taking Tamoxifen citrate from FDA, and is updated regularly. Tamoxifen citrate has active ingredients of tamoxifen citrate. (latest outcomes from Tamoxifen citrate 10,014 users) Dementia (madness) has been reported by people with osteoporosis, high blood pressure, multiple sclerosis, rheumatoid arthritis, depression (latest reports from 24,230 Dementia patients). Dementia (1,712 drugs) Dementia (1,237 conditions) NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on e Health is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Tamoxifen is a selective estrogen receptor modulator (SERM) with mixed agonist/antagonist properties and variable, though consistent, effects upon target tissues. Although tamoxifen confers beneficial properties of an estrogen agonist on bone and on the cardiovascular system, it remains unclear how tamoxifen might influence the central nervous system or cognitive ability. The occurrence of hot flashes, a common side effect of tamoxifen treatment, in approximately 40% of patients implies that this agent exerts effects on the brain; hot flashes are relieved by serotonin uptake inhibitors and are considered to be centrally mediated via brain stem pathways. These phenomena of hot flashes suggest that tamoxifen acts as an estrogen antagonist within the central nervous system, which, in the longer term, could lead to a cognitive deficit. There are limited clinical data indicating that breast cancer treatments that involve combinations of tamoxifen and chemotherapy are associated with impairment of cognitive function provides reassuring evidence that tamoxifen may act as an estrogen agonist in the context of cerebral targets and that it may offer some degree of protection from the cognitive attrition that is associated with aging. Estrogens are thought to have a positive influence on brain metabolism and cognitive function, which is consistent with a 29% reduction in the incidence of Alzheimer's disease among users of hormone replacement therapy compared with nonusers . Longer-term follow-up studies with more rigorous psychometric assessment of patients on tamoxifen treatment are required to confirm any sparing of cognitive loss. Buy propranolol er Prednisone side effects for females Background Concerns have been raised about the risk of dementia associated with antiestrogen adjuvant therapy in breast cancer, but study results have been inconsistent. G. Government support for community action Global Information System on Alcohol and Health General government expenditure on health as a percentage of total government expenditure Health systems Null Results in Brief Null Association between Tamoxifen Use and Dementia in Danish Breast Cancer Patients Anne Gulbech Ording1, Anders Bonde Jensen2, Deirdre Cronin. Here you'll find our latest news as well as a news archive by medical specialty. We have information about research discoveries, new treatments and other announcements about UCSF Benioff Children's Hospital and UCSF Medical Center. If you are a member of the media and need more information, please contact the UCSF News Office at (415) 502-6397 for assistance. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. Tamoxifen is used for hormone-dependent types of breast cancer. It works by blocking the effect of estrogen in the body and thus stopping the growth of cancer cells that possess the estrogen receptors. Since this medication reduces the effects of estrogen, side effects will resemble menopausal symptoms such as hot flashes, vaginal dryness and insomnia. and alzheimers....putting aside the crippled hands issue) leaves me in terror at the notion of any estrogen stripping. Rock and a hard place situation...feeling like a bad patient. 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