If so, how long does it take to make pain and stiffness go away? My dr is using it trying to get rid of all of my joint pain and stiffness that seems to be taking over my body. I had a pretty bad flare right after Christmas and my rheumy added methotrexate to what I was already taking. I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I have noticed an improvement but it's very little. Chloroquine research Hydroxychloroquine sulfate uses Is plaquenil an antibiotic I have mild Lupus with no organ involvement. ANA+. For well over a year I have been experiencing ongoing, unrelenting muscle spasms and stiff, sore legs from the spasms which seem to happen most often in my lower body. I agree with CameronC and all others who are "pro" Plaquenil. I was diagnosed with Limited Systemic Scleroderma in late 2001 & started Plaquenil at the beginning of 2002. Joint and muscle pain and overwhelming fatigue were my worst symptoms. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. He encouraged me to stay with it 3-4 months in order to get the full effect of any help I may receive. However, I think I may be getting migraines from it?! Just remember everyone has a different reaction to the various meds. I don't know if the plaq or MTX or prednisone is what's helping. Plaquenil takes quite a long time to get to its peak effectiveness: depending on what you read, anywhere from 3 months to a year. I also take Cimzia injections bi-weekly but that has only been for about 6 months. Although I do have to give credit to my rheumy because after just a month or two I wanted to be taken off the Cimzia as I didn't think it was really doing much. Hi brandi, I tried Plaquenil, unfortunately for me the side effects is what took me off of it. The kind where I wanted to scratch every inch of my skin off. Took about a week of taking 2 kinds of allergy meds before I got rid of that effect. I have 2 days a week, after my MTX, where I'm just sick. I've been on the MTX now for about a month and when I see my rheumy in 2 weeks I'm going to see if I can try something else or stop taking it. Plaquenil and muscle stiffness Track DMARD Effects - WebMD, Experiences taking Plaquenil for Fatigue and Muscle Pain. Hydroxychloroquine patient britishHydroxychloroquine retinitis pigmentosaHydroxychloroquine or sulfasalazineChloroquine canadaG6pd and hydroxychloroquine Jan 22, 2020 Polymyalgia rheumatica is a form of arthritis. It causes pain in the joints and muscles of the lower back, thighs, hips, neck, shoulder and upper arms, and other parts of the body. The condition occurs when the lining surrounding the joints, bursa and tendons near the shoulders and hips becomes inflamed. Polymyalgia Rheumatica Guide Causes, Symptoms and Treatment.. PLAQUENIL Side Effects, Reviews by Patients -. Hydroxychloroquine - thigh muscle weakness?. Jul 16, 2019 I take both plaquenil and methotrexate MTX. MTX is a chemotherapeutic agent, but autoimmune patients take it at much lower dosages that cancer patients. With the exception of plaquenil, MTX is the immune suppressant with the fewest side effects. It makes a huge difference in how I feel. Jul 16, 2019 Muscle stiffness and joint pain - @conngirl51 - Lupus - 20190716. Ive been off plaquenil for almost a month now after 6 weeks because of chest palpitations. I. Polymyalgia rheumatica is a form of arthritis. It causes pain in the joints and muscles of the lower back, thighs, hips, neck, shoulder and upper arms, and other parts of the body. The condition occurs when the lining surrounding the joints, bursa and tendons near the shoulders and hips becomes inflamed.