Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects. Indications of chloroquine Plaquenil crest syndrome Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Saposin D is released together with three other similar proteins, saposins A, B and C, from a common precursor called prosaposin 1-5precursor is proteolytically processed into mature saposins in late endosomes and lysosomes. Genetic defects of saposins have provided insights into their role in the degradation of sphingolipids. Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation; The Lysosomal Protein Saposin B Binds Chloroquine; Education Ph. D. “Biophysical Chemistry”, University of Paris 7-France 2000 Pre-Doctoral Degree DEA, Ecole Normale Superieure de Cachan ENSC, Paris-France 1997 M. S. Chemistry, Lebanese. While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. Saposin b binds chloroquine The lipid transfer protein Saposin B. Wellcome Open Research, Structural and membrane‐binding properties of saposin D. Plaquenil itchy skinCost of plaquenil uk Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The Lysosomal Protein Saposin B Binds Chloroquine — [email protected] Dr. F. Bou-Abdallah. The Lysosomal Protein Saposin B Binds Chloroquine.. About. My previous research experiences focused on Metal-citrate transport in K. radiotolerans, investigating the binding of human Saposin B to antimalarial drugs, the total synthesis of 8,16. Saposin B SapB is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide sulfatide. SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodystrophy. Given the conformational flexibility and the large hydrophobic “pocket” produced upon physiologically. Atovaquone is a front-line antimalarial drug that functions by competitively inhibiting binding of coenzyme Q10 to the cytochrome bc1 complex. Atovaquone is administered orally, but has low solubility and is poorly absorbed with high variability in bioavailability.