After only 6 weeks, and barely taking half of the supplement "prescription", because I started having reflux, etc. Not entirely sure yet, and to be fair - I've been on Plaquenil since last December. Along with flare and had to back off the vitamins numerous times - nevertheless my cholesterol profile improved tremendously (triglycerides alone came down a whopping 400 points! The doctor cites the malabsorption due to the celiac as the main reason for my osteoporosis and what he called "adult rickets", and my bad cholesterol profile, especially triglycerides comes from Vit B deficiency. Hydroxychloroquine methotrexate price Side effects of hydroxychloroquin Scleroderma plaquenil Chloroquine for cancer I know this is an old post but Jennifer I had a question. I have been taking plaquenil for 7 years. I take 200mg per day. I have sjogrens and cutaneous lupus. MY ANA is homogeneous,SSA 4.6, SSB normal ESR 31. All other lab negative. Recently I had shingles and was given prednisone which then caused an outbreak of HP. Jun 18, 2010 Thank you Lynnwood and Redrose for your responses; they are validating to me. It all makes sense, but it seemed so extreme. To have a positive ANA for so long that suddenly became negative seemed strange to me. Yes, I have been taking Plaquenil since I was diagnosed--so going on four years now. Maybe my ANA went negative because of the Plaquenil.with the other changes, I'm inclined to believe it had quite a lot, if not everything to do with the dietary changes. There was one negative to all the improved bloodwork, and that is that my CRP actually increased doubled, really. I've had less aches and pains since taking triple strength fish oil. Still get fatigued and seem to have flares involving my stomach every 1 - 2 weeks since starting all of this, so I'm investigating and trying to rule out possible causes of that (one of which might be the pharmacy's switch to a different manufacturer of my generic Plaquenil that occurred at the same time). I've been doing a lot of reading and information gathering regarding celiac disease and autoimmune disease and there are so many links! ) My Vit D improved from 17 to 26 (I barely took any Vit D) a high parathyroid level returned to a normal range, and my ANA was negative for the first time in 3 years. I've never been able to stay on a statin drug - all caused major side effects. Can plaquenil cause a negative ana A negative ANA? DailyStrength, Positive ANA at 80 and now negative. Plaquenil octWill plaquenil help sjorgrens rashChloroquine or prophylaxisHydroxychloroquine sulfate allergy Dec 27, 2010 But have been on Medrol, Plaquenil, and only a short time of Cellcept. My ANA went neg. But since they weaned me from 10 mg Medrol to 8- then had the eye problems, chills, diarrhea, etc, then to 6 mg, again with chills, eye problems, etc, the ANA went to 40 then 80 which I know is very low compared to before, but why does it do this? Do steroids and Plaquenil change the ANA results? Lupus.. ANA - positive to negative -. Lupus How can an ANA blood test go from positive to negative. I know that there are many causes for a positive ANA, but does a negative ANA mean someone doesn't have lupus? Is there cause for these doctors to change their minds, or is it that many doctors just know so little about lupus, that they doubt their original dx? It would be great if you could shed a little light on this for all of us. But Plaquenil could help someone ANA-negative for a few reasons that I've read about. First, maybe you do have positive ANA & positive autoantibodies, but all your bloodwork was done when those levels had fallen. Then there's that rare kind of SLE called Ro-lupus. Also, in the discoid lupus "subset", people remain ANA-negative. The Rheum MD just called telling me my labs were normal and my ANA was just under 1.6 & Vit D 34 abn less 30 so he felt I did not have Lupus but to stay on the Lyrica. He said my other labs were also normal. My concern is that I have been on Plaquenil for a while now, can it cause a false negative ANA?