Keep in mind that most people with Sjogren's stay healthy and don't have serious problems. You should be able to keep doing all the things you love to do without making many changes. Ra plaquenil success rates Plaquenil overdose symptoms Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. My rheumy has saidand everything I've read on Plaquenil that Plaquenil NEEDS that amount of time to build in your system before it stats to have beneficial. In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias joint pain, dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” Conditions like this are called autoimmune diseases. Sjogren's causes your immune system to go haywire and attack healthy cells instead of invading bacteria or viruses. Build up of plaquenil symptoms Fighting Lupus Fatigue and Boosting Energy, Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Robitussin dm and hydroxychloroquine He told me it would take 3 months for it to build up enough to work. The only major side effect, and it is major, is that sometimes in can build up in the eye and damage vision. But it is something they can catch easily. I had to have a baseline image of my eyes with a kind of fluoroscope before starting the Plaquenil. Plaquenil - how long for side effects to subside?. The Risk of Retinal Toxicity with Plaquenil. Clogged arteries Signs and symptoms of arterial plaque. Symptoms. The symptoms of Sjogren's vary a lot from person to person. You may have just one or two, or you may have many. By far, the most common symptoms are Dry mouth. In cutaneous porphyria, the porphyrins build up in the skin, and when exposed to sunlight, cause symptoms. In acute porphyrias, the buildup damages the nervous system. Genetic forms. Most forms of porphyria are inherited. Porphyria can occur if you inherit A defective gene from one of your parents autosomal dominant pattern Plaquenil and its affect on the immune system. But Plaquenil, in it's original form is probably the first "drug discovered by man. It can build up in.