Canine extramedullary plasmacytomas (atypical histiocytomas, cutaneous neuroendocrine tumors [see Primary Cutaneous Neuroendocrine Tumors], reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. Although their derivation was long debated, neoplastic cells characteristically express cytoplasmic immunoglobulin and may produce primary amyloid, leaving little doubt as to their lymphoplasmacytic origin. These tumors of dogs and, rarely, cats are most frequently identified on the head (including ears, lips, and oral cavity) and extremities of mature to aged animals. Cocker Spaniels, Airedales, Scottish Terriers, and Standard Poodles are most at risk. The tumors are generally small ( Cutaneous lymphosarcoma may occur as a disease in which the skin is the initial and primary site of involvement, or it may be secondary to systemic, internal disease. (See also Canine Lymphoma; see Bovine Leukosis; and see Feline Leukemia Virus and Related Diseases.) 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