Chloroquine synthesis mechanism

Discussion in 'Canada Drug' started by MoOoN, 19-Mar-2020.

  1. bratezz User

    Chloroquine synthesis mechanism


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    The uncharged chloroquine is the only membrane permeable form of the molecule and it freely diffuses into the erythrocyte up to the DV. In this compartment, chloroquine molecules become protonated and, since membranes are not permeable to charged species, the drug accumulates into the acidic digestive vacuole 3. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Although the precise mechanism by which chloroquine exerts anticancer effects is unclear, 1 possible mechanism is its antiautophagic activity. Autophagy is 1 of the physiologic processes affected by chloroquine.

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    Chloroquine synthesis mechanism

    Design and Synthesis of Novel Chloroquine-based Antimalarials, Chloroquine - FDA prescribing information, side effects.

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  5. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial.

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    A New Synthesis of Chloroquine Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

     
  6. SANR Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine and Chloroquine Retinopathy David J. Hydroxychloroquine Side Effects, Dosage, Uses, and More Eye screening for patients taking hydroxychloroquine Plaquenil®
     
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    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Published evidence says that it is mediated by T-lymphocytes. Central centrifugal cicatricial alopecia DermNet NZ Frontal Fibrosing Alopecia The Trichological Society Lichen Planopilaris Treatment Dermatology Education
     
  8. VikaPoleva Guest

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