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  1. msdnaa New Member

    Nolvadex on cycle


    Nolvadex is one of the Selective Estrogen receptor modulators (SERMs) family of drugs. SERMs are part of the larger family of drugs called anti-estrogens. The other subdivision of drugs that fall under the anti-estrogens class is called the aromatase inhibitors (AIs) and includes drugs like Arimidex (Anastrozole) and Aromasin (Exemestane). SERMs and Aromatase inhibitors differ on the lines of how they work on matters of estrogen control. Contrary to common perception that SERMs like Clomid and Nolvadex work by lowering the levels of estrogen, they fill up the receptor sites in breast tissue hence blocking the actions of Estrogen. This way, the Estrogen is prevented from exerting its effect at the site by getting attached to the receptorsite. Additionally, Nolvadex, like other SERMs occupy receptor sites in cells of organs like the liver and act as Estrogens. SERMs do not work by lowering the amountslof Estrogen in plasma. – A concern about anabolic steroid use is the resulting suppression of natural testosterone production. During an anabolic steroid cycle itself, this suppression is unavoidable and isn’t necessarily a problem. However, extended post-cycle suppression results in loss of gains and can result in adverse side effects such as depression and loss of libido. In contrast, where recovery of natural testosterone production is rapid, adverse effects on mood or libido can be reduced or eliminated, and retention of gains can be excellent. Post-cycle therapy (PCT) with Nolvadex was introduced specifically to enable faster recovery. To understand how Nolvadex can speed recovery, it’s important to understand how inhibition occurs, and how it may be reversed by a selective estrogen receptor modulator (SERM) such as Nolvadex. Testosterone production is regulated in a chain process.

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    What is a SERM? Nolvadex and Chlomid Explained SERM is an acronym that stands for Selective Estrogen Receptor Modulator. SERMs bind with estrogen receptors, blocking some estrogen actions while at the same time permitting others. Dear Friend and Fellow Athlete, In bodybuilding, Nolvadex Tamoxifen Citrate is used as both an anabolic steroid cycle ancillary drug and as recovery or as a post. Nolvadex belongs to a class of medications known as selective estrogen receptor modulators, more commonly known as SERMs. These drugs help to block the effects of.

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not to exceed 500 mg/dose, OR 10 mg/kg IV q8-12hr x 10-21 days; not to exceed 400 mg/dose Postexposure therapy IV: 10 mg/kg q12hr for 60 days; individual dose not to exceed 400 mg PO: 15 mg/kg q12hr for 60 days; individual dose not to exceed 500 mg Change antibiotic to amoxicillin as soon as penicillin susceptibility confirmed Nausea (3%) Abdominal pain (2%) Diarrhea (2% adults; 5% children) Increased aminotransferase levels (2%) Vomiting (1% adults; 5% children) Headache (1%) Increased serum creatinine (1%) Rash (2%) Restlessness (1%) Acidosis Allergic reaction Angina pectoris Anorexia Arthralgia Ataxia Back pain Bad taste Blurred vision Breast pain Bronchospasm Diplopia Dizziness Drowsiness Dysphagia Dyspnea Flushing Foot pain Hallucinations Hiccups Hypertension Hypotension Insomnia Irritability Joint stiffness Lethargy Migraine Nephritis Nightmares Oral candidiasis Palpitation Photosensitivity Polyuria Syncope Tachycardia Tinnitus Tremor Urinary retention Vaginitis Acute generalized exanthematous pustulosis (AGEP), erythema multiforme, exfoliative dermatitis, fixed eruption, photosensitivity/phototoxicity reaction Agitation, confusion, delirium Agranulocytosis, albuminuria, serum cholesterol and TG elevations, blood glucose disturbances, hemolytic anemia, marrow depression (life threatening), pancytopenia (life threatening or fatal outcome), potassium elevation (serum) Anaphylactic reactions (including life-threatening anaphylactic shock), serum sickness like reaction, Stevens-Johnson syndrome Anosmia, hypesthesia Constipation, dyspepsia, dysphagia, flatulence, hepatic failure (including fatal cases), hepatic necrosis, jaundice, pancreatitis Hypertonia, hypotension (postural), increased INR (in patients treated with Vitamin K antagonists), QT prolongation, torsade de pointes, ventricular arrhythmia Methemoglobinemia Myasthenia, exacerbation of myasthenia gravis, myoclonus, nystagmus, peripheral neuropathy that may be irreversible, phenytoin alteration (serum), polyneuropathy, psychosis Myalgia, tendinitis, tendon rupture, toxic epidermal necrolysis (Lyell’s Syndrome), twitching Infections: Candiduria, vaginal candidiasis, moniliasis (oral, gastrointestinal, vaginal), pseudomembranous colitis Renal calculi Vasculitis Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated UTIs, that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options Use in pregnancy, though generally contraindicated for all quinolones, is allowed for life-threatening situations; limited data from use of ciprofloxacin in pregnancy show no higher rate of birth defects than background Do not use oral suspension in nasogastric tube; to prepare, add microcapsules to diluent Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion); these reactions can occur within hours to weeks after starting therapy, including in patients of any age or without pre-existing risk factors; discontinue therapy immediately at first signs or symptoms of any serious adverse reaction; in addition, avoid use of fluoroquinolones, in patients who have experienced any serious adverse reactions associated with fluoroquinolones (see Black Box Warnings) Peripheral neuropathy: sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias, and weakness reported; peripheral neuropathy may occur rapidly after initiating and may potentially become permanent In prolonged therapy, perform periodic evaluations of organ system functions (eg, renal, hepatic, hematopoietic); adjust dose in renal impairment; superinfections may occur with prolonged or repeated antibiotic therapy; discontinue use immediately if signs and symptoms of hepatitis occur Not first drug of choice in pediatrics (except in anthrax), because of increased incidence of adverse events in comparison with control subjects, including arthropathy; no data exist on dosing for pediatric patients with renal impairment (ie, Cr Cl Distributed widely throughout body; tissue concentrations often exceed serum concentrations, especially in kidneys, gallbladder, liver, lungs, gynecologic tissue, and prostatic tissue; cerebrospinal fluid (CSF) concentration is 10% in noninflamed meninges and 14-37% in inflamed meninges; crosses placenta; enters breast milk Protein bound: 20-40% Vd: 2.1-2.7 L/kg Additive: Aminophylline, amoxicillin, amoxicillin-clavulanate, amphotericin, ampicillin-sulbactam, ceftazidime, cefuroxime, clindamycin, floxacillin, heparin, piperacillin, sodium bicarbonate, ticarcillin Y-site: Aminophylline, ampicillin-sulbactam, azithromycin, cefepime, dexamethasone sodium phosphate, furosemide, heparin, hydrocortisone sodium succinate, magnesium sulfate(? ), methylprednisolone sodium succinate, phenytoin, potassium phosphates, propofol, sodium bicarbonate(? ), sodium phosphates, total parenteral nutrition formulations, warfarin Solution: Compatible with most IV fluids Additive: Amikacin, aztreonam, dobutamine, dopamine, fluconazole, gentamicin, lidocaine, linezolid, metronidazole (ready-to-use form is compatible; hydrochloride form in vial is incompatible), midazolam, potassium chloride, tobramycin Y-site: Amiodarone, calcium gluconate, clarithromycin, digoxin, diphenhydramine, dobutamine, dopamine, linezolid, lorazepam, midazolam, promethazine, quinupristin/dalfopristin, tacrolimus The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Cipro Ciprofloxacin Side Effects, Interactions, Warning, Dosage. Bioterrorism and Drug Preparedness Ciprofloxacin Use by Pregnant. Ciprofloxacin 500 mg film-coated tablets - Patient Information Leaflet.
     
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    What Are the Pros and Cons of Amoxicillin for Babies? Amoxicillin is a form of penicillin antibiotic regularly prescribed for adults as well as infants and babies. While this drug is usually safe and beneficial in treating the commonplace infections that trouble infants and babies, it is capable of producing side effects that include, stomach upset, rash and, according to some experts, damage to permanent teeth.

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