Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Hydroxychloroquine in rheumatoid arthritis mechanism of action Plaquenil and vision side effects Please I need to find out if anyone who has taken plaquenil has experienced back and hip pain. I started in Oct of 2011 taking 200 mg of plaquenil once a day. In April of 2012 I started taking 400 mg 2 x's a day. I did start to notice that I was having pain when I tried to sleep at night. Mostly in my arms hands and ankles. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? Plus I will be honest the whole eye site thing even though rare has always freaked me out. I went off of it to see if I can manage not being on it as my lupus isnt as severe as other cases but already I am feeling very fatigued and my legs feel heavy if that makes sense. I can discuss alternatives with my DR at my next appt but my DR feels as though the plaq is the best bet for my level of illness. If so are you just dealing with Lupus symptoms or did you take another med? I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. Plaquenil for chronic pain Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Had to stop taking Plaquenil - Chronic Illness Community. Caffeine and plaquenilHydroxychloroquine tirednessAverage dose for plaquenil is 1 tablet dailyChloroquine and ciprofloxacin for typhoid prophylaxisChloroquine protocol for travel Neuralgia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Humira, and have Pain. Will you have Neuralgia with Plaquenil - eHealthMe. Inflammatory Osteoarthritis And Plaquenil. Plaquenil Pain Relief - Relief Your Chronic & Shoulder.. PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. Rheumatoid Arthritis. PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults. At one time I was taking plaquenil but now use methotrexate. Plaquenil is an antimalareial med. It has an anti-inflammatory effect simular to NSAiDs.helps joint pain and reduces muscle inflammation. Fibro is not an inflammatory process. While I was on it, it did nothing to help the everyday achiness of fibro. Plaquenil will also help with rashes. Find information about common, infrequent and rare side effects of Plaquenil Oral.