However, I read somewhere that in "immunocompromised" individuals, a fifth shot is given. So my question is, are people with Sjogren's alone, immunocompromised? I looked up the definition of "immunocompromised" and it seems to apply to people who take immunosuppressive drugs or have "certain kinds of cancer". If you are on prednisone, methotrexate or another immunosuppressant you are immunocompromised. Diseases treated with plaquenil How to wean off hydroxychloroquine Up to 50% of lupus patients may have non-life threatening symptoms such as fatigue, joint pain, and rash. Non-steroidal anti-inflammatories e.g. ibuprofen and antimalarials Plaquenil are frequently used for symptomatic relief in this case. Even in cases of mild disease, regular monitoring is critical In rare cases, Plaquenil can adversely affect the eyes, and patients taking this medicine should be seen by an ophthalmologist at least once a year. Leflunomide works. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Being diagnosed with Sjogrens doesnt mean you are immunocompromised, but it can occur if antibodies attack your WBCs. If your WBC count is low you would be considered immunocompromised. Plaquenil immunocompromised Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., DMARDs for Treating Rheumatoid Arthritis Plaquenil antimalarial drugChloroquine hydrochloride tabletsCan you take plaquenil at night Atovaquone-proguanil is contraindicated for use in the treatment prophylaxis of plasmodium falciparum malaria in patients with severe renal impairment CrCl less than 30 mL/min. Rarely, cases of anaphylaxis following treatment with atovaquone-proguanil have been reported. Atovaquone / Proguanil Dosage Guide with Precautions -. Hydroxychloroquine Plaquenil. Are people with Sjogren's considered "immunocompromised"?. Methotrexate is the cornerstone of treatment for RA and has demonstrated efficacy not only in treating the symptoms of RA but also to prevent the development of joint damage. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Higher doses of medications that weaken your immune system are more likely to increase your risk of getting a fungal infection. 5,11,13,14. Click on the sections below to see lists of corticosteroids and TNF inhibitors that can increase the chances of getting a fungal infection. Any one have any experience or info regarding pre-existing precancerous conditions and the effects of Plaquenil on the immune system. I see so much info on the net where some says that Plaquenil has very mild effect on immune system except for eye issues --- Other info says it is an immunosuppressant.