Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine for vivax malaria Methotrexate and plaquenil interaction Hydroxychloroquine side effects fluid retention Hydroxychloroquine instructions Hydroxychloroquine Interactions Avoid taking an antacid or Kaopectate kaolin-pectin within 4 hours before or after you take hydroxychloroquine. Some antacids can make it harder for your body to. Prednisone is a bone killer as I’m paying the price 25 years later, but I was pretty pain free all those years! No hair loss and plaquenil has not affected my eyes other than dry eyes. Keep a diary of your meds. I have been on prednisone for 15 months and am down to 5 mg. I cannot seem to get below that dose without having a flate. My rheumatologist has started me on Plaquenil and has said this should help me get off the prednisone. He said he would rather see me on Plaquenil instead of prednisone due to less side effects of the Plaquenil. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prednisone and hydroxychloroquine interaction Prednisone Drug Interactions - Drugs Home Page, Plaquenil and Prednisone Hydroxychloroquine for lichen sclerosus lichen planus eye side effectsPlaquenil and excessive sweating Plaquenil hydroxychloroquine and prednisone are used to treat symptoms of rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Prednisone is also used to treat or manage many conditions. Plaquenil vs. Prednisone Prescription Treatment for.. Plaquenil? I have been on prednisone for 15 months.. Prednisone and Plaquenil question" Lupus Community.. Although prednisone rarely has a direct interaction with other medications, there is an increased risk of infection when combining prednisone with other medications that affect your immune system. Additionally, when taking prednisone with NSAIDs such as naproxen or ibuprofen, there can be an increased risk of stomach ulcers. Digoxin, cyclosporine, and certain beta blockers may cause drug interactions with hydroxychloroquine. This eMedTV segment explores what may happen if these drugs are taken with hydroxychloroquine and lists other drugs that may cause an interaction. If you take medications such as estrogens or barbiturates with prednisone, drug interactions may potentially occur. These interactions can increase your risk of side effects, affect the level of prednisone in your blood, or decrease the effectiveness of some medications.