Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Rheumatoid arthritis chloroquine Chloroquine interactions Hydroxychloroquine eye issues I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Your rheumatologist will likely try the pills first because most people don’t want shots. Oral methotrexate is available in 2.5 mg tablets. For adults with RA, the starting dose of methotrexate is usually around 7.5 to 15 mg a week three to six tablets. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine increase metroxtrate Rheumatoid Arthritis Medication Beware of Sunburn if You., Common Questions About Taking Methotrexate for Rheumatoid. Natural antibiotics for lyme plaquenil Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. Combination therapy with methotrexate and.. Hydroxychloroquine - Wikipedia. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Hydroxychloroquine and. Methotrexate's biggest advantage could be that it has been shown to be safe to take for long periods of time and can even be used in children. increase energy. RA. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks.