I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. Aralene Chloroquine solution storage Plaquenil photosensitivity rash cheeks In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias joint pain, dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” Plaquenil is primarily used to help with some of the symptoms of Sjogren's.reduce fatigue, and joint pain. It is also thought it help slow progression but not well documented for this. It is not expected to halt the disease process and reverse your SFN. Specifically, anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis inflammation of the lining of the heart, pleuritis inflammation of the lining of the lung, and other lupus symptoms such as fatigue and fever. I felt the Plaquenil helped the fatigue, but it seems the pain is sabotaging that effect. My knees and legs hurt, back, hips, shoulders, fingers, and now my left heel - which has me limping half the time. Can plaquenil cause joint pain Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil causes and treats neuropathy? - NeuroTalk Support. Can you take hydroxychloroquine sulfate if youre allergic to.sulfaPlaquenil visual field defectsHydroxychloroquine onlineChloroquine and bafilomycinDo i need prescription for chloroquine phosphate I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. Stomach problems with Plaquenil • Johns Hopkins Arthritis Center. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Plaquenil has helped my muscle/joint pain immensely. Have you considered that Lupus may be throwing some inflammation your way - ie joint/muscle pain, a Lupus flare - rather than blaming a medication that in general decreases those symptoms? I noticed plaquenil helping with my fatigue more so than anything else. It does help my joint pain but I need extra help from other meds too It can take up to 6 months to get in your system and fully work, each person is different. I pray it doesn't take that long for you to get some relief. Plaquenil has relieved debilitaing hip, shoulder knee, and other small joint pain. If you try this med, get your eyes checked frequently, and do not get discouraged-it can take up to 6 months before the med starts to work.