You should not use this medication if you have a serious heart problem (heart block, sick sinus syndrome, slow heart rate), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting. Metoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Metoprolol may also be used for other purposes not listed in this medication guide. You should not use this medication if you are allergic to metoprolol, or other beta-blockers (atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others), or if you have: Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. If you are being treated for high blood pressure, keep using this medication even if you feel well. You may need to use blood pressure medication for the rest of your life. Other drugs may interact with metoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Do not take this medicine in larger or smaller amounts or for longer than recommended. While using metoprolol, you may need frequent blood tests at your doctor's office. If you need surgery, tell the surgeon ahead of time that you are using metoprolol. Not all possible interactions are listed in this medication guide. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Absorption: Well absorbed after oral administration. Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk. Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2D6; the CYP2D6 enzyme system exhibits genetic polymorphism); ~7% of population may be poor metabolizers and may have significantly ↑ metoprolol concentrations and an ↑ risk of adverse effects. TIME/ACTION PROFILE (cardiovascular effects)When switching from immediate-release to extended-release product, the same total daily dose can be used PO: (Adults) Antihypertensive/antianginal– 25–100 mg/day as a single dose initially or 2 divided doses; may be ↑ q 7 days as needed up to 450 mg/day (immediate-release) or 400 mg/day (extended-release) (for angina, give in divided doses). MI– 25–50 mg (starting 15 min after last IV dose) q 6 hr for 48 hr, then 100 mg twice daily. Heart failure– 12.5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day. Migraine prevention– 50–100 mg 2–4 times daily (unlabeled). IV: (Adults) MI– 5 mg q 2 min for 3 doses, followed by oral dosing. Tablets (tartrate): 25 mg, 50 mg, 100 mg Cost: Generic: All strengths $7.18/100Extended-release tablets (succinate; Toprol XL): 25 mg, 50 mg, 100 mg, 200 mg Cost: Generic: 25 mg $35.68/100, 50 mg $41.93/100, 100 mg $53.95/100, 200 mg $84.54/100Solution for injection: 1 mg/m LIn Combination with:hydrochlorothiazide (Dutoprol, Lopressor HCT). See combination drugs.metoprolol is a sample topic from the Davis's Drug Guide.
Item #, 814415. NDC, 00378-0018-05. Manufacturer. MYLAN. Package Size, 500. UOM, EA. Case Qty, 72. Strength, 25MG. Fed. Rating, AB. Color, WHITE. Mgkg−1 LD50, Ratte, oral; 2090 mgkg−1 LD50, Maus, oral, Tartrat. Soweit möglich und gebräuchlich, werden SI-Einheiten verwendet. Wenn nicht anders vermerkt, gelten die angegebenen Daten bei Standardbedingungen. Metoprolol ist ein Arzneistoff aus der Gruppe der selektiven β1- Adrenorezeptorenblocker. Summenformel, C15H25NO3.