This list includes common and less common side effects for individuals taking Prednisolone. Prednisolone side effects that are very rare, occurring in less than 10% of patients, are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms. Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: You will be checked regularly by your health care professional while you are taking Prednisolone, to monitor side effects and check your response to therapy. Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys and liver) will also be ordered by your doctor. Corticosteroids are naturally produced by the adrenal gland in the body. Corticosteroids influence the functioning of most of the body's systems (heart, immune, muscles and bones, endocrine and nervous system). Anabolic steroids are very useful in treating patients with severe burns that require assistance regenerating tissue, patients infected with the HIV virus who have lost significant weight, patients who have intestinal diseases that inhibit their ability to absorb food, and cancer patients who are losing weight and have appetite loss as a result of chemotherapy. Prednisone is sometimes part of the treatment plan for various types of lymphomas, leukemia, and bronchitis. It is also sometimes used to suppress the immune system of individuals who have organ transplants to lessen the chances of the body rejecting the new organ. The drug has significant medical utility, and it is not a drug that is highly sought after by bodybuilders, athletes, etc., because it is not an anabolic steroid. Prednisone is typically taken orally, but corticosteroids like prednisone can be used in topical medications. The side effect profile of prednisone is relatively benign, and few individuals experience side effects. According to the Food and Drug Administration (FDA), the most common side effects of prednisone include: Although there are side effects associated with the use of any medication, prednisone is typically well tolerated in most individuals.
Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. The NICE British National Formulary (BNF) and British National Formulary for Children (BNFc) sites are only available to users in the UK, Crown Dependencies and British Overseas Territories. If you believe you are seeing this page in error please contact us.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic. Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn about side effects, interactions and indications.