Fluconazole use

By: avram Date: 20-Feb-2019
<i>Fluconazole</i> Oral <i>Uses</i>, Side Effects, Interactions.

Fluconazole Oral Uses, Side Effects, Interactions.

uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) e Methodse Referencese Table 1. Variables Included in Propensity Score with Categories, Sources of Data, Missing Values, and Imputed Valuese Table 2. Standardized Differences Between Fluconazole-Exposed and Unexposed Pregnancies Before and After Matching Based on Propensity Scores, Maternal Age, Calendar Year, and Gestational Agee Table 3. Pub Med Google Scholar Crossref Rassen JA, Shelat AA, Myers J, Glynn RJ, Rothman KJ, Schneeweiss S. Pub Med Google Scholar Crossref Xu R, Luo Y, Chambers C. Association Between Itraconazole Exposure in Pregnancy and the Risk of Spontaneous Abortione Figure. Some methods of propensity-score matching had superior performance to others: results of an empirical investigation and Monte Carlo simulations . One-to-many propensity score matching in cohort studies . Assessing the effect of vaccine on spontaneous abortion using time-dependent covariates Cox models . Time Window of Exposure and Risk Window of Spontaneous Abortion and Stillbirth Cotch MF, Hillier SL, Gibbs RS, Eschenbach DA; Vaginal Infections and Prematurity Study Group. Pub Med Google Scholar Crossref Inman W, Pearce G, Wilton L. Pub Med Google Scholar Crossref Mastroiacovo P, Mazzone T, Botto LD, et al. Pub Med Google Scholar Crossref Nørgaard M, Pedersen L, Gislum M, et al. Pub Med Google Scholar Crossref Wilton LV, Pearce GL, Martin RM, Mackay FJ, Mann RD. Epidemiology and outcomes associated with moderate to heavy Candida colonization during pregnancy . Safety of fluconazole in the treatment of vaginal candidiasis: a prescription-event monitoring study, with special reference to the outcome of pregnancy . Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole . Maternal use of fluconazole and risk of congenital malformations: a Danish population-based cohort study . The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England .

Diflucan <i>fluconazole</i> dosing, indications, interactions.

Diflucan fluconazole dosing, indications, interactions.

QT prolongation Torsades de pointes Alopecia Anaphylactic reactions Angioedema Cholestasis Dizziness Dyspnea Hepatic failure Hepatitis Hypertriglyceridemia Hypokalemia Increased alkaline phosphatase Increased ALT/AST Jaundice Leukopenia Pallor Seizures Stevens-Johnson syndrome Taste perversion Thrombocytopenia Toxic epidermal necrolysis Hypersensitivity to other azoles Use caution in proarrhythmic conditions and renal impairment Use extreme caution or avoid in congenital long-QT patients and patients with conditions that increase QT-prolongation risk Fluconazole inhibits CYP2C9, CYP2C19, and CYP3A4 isoenzymes; coadministration with drugs that are substrates if these isoenzymes may be contraindicated or warrant dosage modifications Capsules contain lactose and should not be given to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Powder for oral suspension contains sucrose and should not be used in patients with hereditary fructose, glucose/galactose malabsorption or sucrase-isomaltase deficiency Syrup contains glycerol; may cause headache, stomach upset, and diarrhea Hepatotoxicity reported with use; use with caution in patients with hepatic impairment Rare exfoliative skin disorders reported; monitor closely if rash develops and discontinue if it progresses When driving vehicles or operating machines, it should be taken into account that dizziness or seizures may occasionally occur Candida krusei is inherently resistant Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole (26%) versus intravaginal agents (16%) If drug is used during pregnancy or if patient becomes pregnant while taking the drug, patient should be informed of potential hazard to fetus; effective contraceptive measures should be considered in women of child-bearing potential who are being treated with 400 to 800 mg/day and should continue throughout the treatment period and for approximately 1 week (5 to 6 half-lives) after the final dose Highly selective inhibitor of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase Subsequent loss of normal sterols correlates with accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole Additive: TMP-SMX Y-site: Amphotericin B, amphotericin B cholesteryl sulfate, ampicillin, calcium gluconate, cefotaxime, ceftazidime(? ), ceftriaxone, cefuroxime, chloramphenicol, clindamycin, co-trimoxazole, diazepam, digoxin, erythromycin lactobionate, furosemide, haloperidol, hydroxyzine, imipenem/cilastatin, pentamidine, piperacillin, ticarcillin, TMP-SMX Solution: D5W, LR Additive: Acyclovir, amikacin, amphotericin B, cefazolin, ceftazidime, ciprofloxacin, clindamycin, gentamicin, heparin, meropenem, metronidazole, morphine, piperacillin, potassium chloride, ranitidine with ondansetron, theophylline Y-site: Acyclovir, aldesleukin, allopurinol, amifostine, amikacin, aminophylline, amiodarone, ampicillin-sulbactam, aztreonam, benztropine, bivalirudin, cefazolin, cefepime, cefotetan, cefoxitin, cefpirome, chlorpromazine, cimetidine, cisatracurium, dexamethasone sodium phosphate, dexmedetomidine, diltiazem, diphenhydramine, dobutamine, docetaxel, dopamine, doxorubicin liposomal, droperidol, etoposide PO4, famotidine, fenoldopam, filgrastim, fludarabine, foscarnet, ganciclovir, gatifloxacin, gemcitabine, gentamicin, granisetron, heparin, hetastarch, hydrocortisone, immune globulin, leucovorin, linezolid, lorazepam, melphalan, meperidine, meropenem, metoclopramide, metronidazole, midazolam, morphine, nafcillin, nitroglycerin, ondansetron, oxacillin, paclitaxel, pancuronium, penicillin G, phenytoin, piperacillin-tazobactam, prochlorperazine, promethazine, propofol, quinupristin-dalfopristin, ranitidine, remifentanil, sargramostim, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin-clavulanate, tobramycin, vancomycin, vecuronium, vinorelbine, zidovudine Tablets: Store below 86° F (30° C) Dry powder: Store below 86° F (30° C); reconstituted suspension should be stored between 86° F (30° C) and 41° F (5° C), and unused portion should be discarded after 2 weeks; protect from freezing Injection (glass bottles): Store between 86° F (30° C) and 41° F (5° C); protect from freezing Injection (Viaflex Plus plastic containers): Store between 77° F (25° C) and 41° F (5° C); protect from freezing The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. In New Zealand, fluconazole is available as 50 mg, 150 mg and 200 mg capsules on prescription (Diflucan®). There is also a 2 mg/ml injection for intravenous use. In New Zealand, Pharmaceutical Schedule subsidy of the capsules requires Specialist recommendation. Fluconazole binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall. Fluconazole is well absorbed orally with or without food. It takes 22 to 30 hours for half of the medication to be cleared from the blood stream and may take several days of continuous treatment to reach a steady concentration. The drug is eliminated unchanged in the urine so doses should be reduced if there is kidney disease. For versicolor, either 50 mg daily or 150 mg once weekly is taken for two to six weeks.

Drug Safety and Availability FDA Drug Safety CommunicationUse of.
Drug Safety and Availability FDA Drug Safety CommunicationUse of.

Aug 3, 2011. FDA Drug Safety CommunicationUse of long-term, high-dose Diflucan fluconazole during pregnancy may be associated with birth defects in. Fluconazole is an antifungal medicine. Fluconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat,

Fluconazole use
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