Here we go again: another generic metoprolol recall from an Indian drug company. Reddy’s metoprolol succinate 25 mg extended release tablets and the company is in the process of recalling 1,356,000 pills. Toprol-XL (metoprolol) is a beta blocker in the same family as atenolol and propranolol. Tens of millions of people swallow beta blockers every day to control heart rate, reduce the risk of a second heart attack, prevent migraines and ease the pain of angina. The original brand name medicine was developed under the name Lopressor and was an immediate release product. That means it had to be taken up to four times daily. The extended-release formulation, Toprol-XL, was approved in 1992 and was given once daily, making it far more patient friendly. We first suspected that there might be problems with generic extended release metoprolol succinate in 2007. Readers of our newspaper column and visitors to our website began reporting therapeutic failures when they were switched from Toprol-XL to metoprolol succinate. Here are just a few of their reports: “After taking Toprol XL with good results for three years to control cardiac arrhythmias, I was given a generic substitute three weeks ago when I switched pharmacies. I have a blood pressure cuff that records my last 100 readings. “After taking the daily dosage for five days, I began having more and more arrhythmias to the point of having to be admitted to the hospital. “After discharge, I returned to the unused brand name drug (Toprol XL) and have had no further problems.” Nancy, March 20, 2007“I have been taking brand name Toprol XL for quite some time without any problems. During about the first 12 hours after taking it, my blood pressure was way too low. Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. Metoprolol is sold in formulations that can be taken by mouth or given intravenously. Side effects, especially with higher doses, include dizziness, drowsiness, fatigue, diarrhea, unusual dreams, trouble sleeping, depression, and vision problems. Metoprolol may also reduce blood flow to the hands or feet, causing them to feel numb and cold; smoking may worsen this effect. Due to the high penetration across the blood-brain barrier, lipophilic beta blockers such as propranolol and metoprolol are more likely than other less lipophilic beta blockers to cause sleep disturbances such as insomnia and vivid dreams and nightmares. Serious side effects that are advised to be reported immediately include symptoms of bradycardia (resting heart rate slower than 60 beats per minute), persistent symptoms of dizziness, fainting and unusual fatigue, bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction, hair loss, mental/mood changes, depression, breathing difficulty, cough, dyslipidemia and increased thirst.
The FDA has just announced that a maker of generic Toprol XL will have to recall 109,744 bottles of metoprolol succinate. That could represent a substantial number of pills. Wockhardt is a large Indian drug maker and it has supplied roughly one-fourth of the metoprolol swallowed each year in the U. Although the FDA previously stated that all the generic metoprolol products it had tested passed initial dissolution testing, a new announcement released on May 14, 2014, reveals that Wockhardt’s metoprolol actually failed this crucial test. The implications are significant regarding FDA’s oversight of metoprolol in particular and generic drugs in general. Let’s start at the beginning of this tale of woe and intrigue. In 2007 we started receiving messages from visitors to this website that a beta blocker heart and blood pressure medicine called Toprol XL was not working as well as expected in its generic form, metoprolol. As more and more complaints poured in, we contacted the FDA about our concerns. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks. When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Get medical help right away if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat. Show More This medication is a beta-blocker used to treat chest pain (angina), heart failure, and high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Our drug coverage changed and the mail order drug company sent me the generic metoprolol succinate ER tabs. His best-selling book, The People’s Pharmacy. Metoprolol learn about side effects. you or your doctor may send a report to the Food and Drug Administration's. Generic alternatives may be available.