If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. By activating your account, you will create a login and password. Tamoxifen (Nolvadex) is effective in preventing and treating estrogen receptor-positive (ER ) breast cancer. Women who complete their prescribed anti-estrogen treatments have been found to have better recurrence and survival profiles than women who do not. There are some foods that appear to enhance the effectiveness of tamoxifen treatment and others that reduce it. Tamoxifen is associated with higher risk of endometrial cancer for women who have not had a hysterectomy and higher risk of developing blood clots, among other side effects. However, there are some foods that can protect against endometrial cancer and blood clots while not interfering with tamoxifen's effectiveness. Certain selective serotonin reuptake inhibitor (SSRI) antidepressants such as Paxil (paroxetine) and Prozac (fluoxetine), as well as the serotonin antagonist and reuptake inhibitor Oleptro (trazodone), have been found to interfere with tamoxifen treatment in some women. Exposure to light at night suppresses melatonin production, which in turn can lead to tamoxifen resistance. Regular aspirin use appears to enhance the effectiveness of tamoxifen.
Aspirin May Halt Cancer By Acting on Cancer Stem Cells. In their study, they found aspirin boosted the effect of tamoxifen, which is used to. Like the other NSAIDs, aspirin inhibits both COX-1 and COX-2. Breast cancer is a hormonally responsive disease, and tamoxifen works.