If you’ve been taking Zoloft daily and significantly reduce doses – or quit completely – you can expect to go through withdrawal. More on the duration of Zoloft withdrawal, possible side effects, and how to ease the discomfort here. In this article, we’ll explain the withdrawal process and let you know what happens each step of the way. Additionally we talk about the importance of seeking medical help during the process. And at the end of the article, you’ll find a list of recommendations about how to quit Zoloft safely. Finally, we welcome all your questions in the comments section at the end. We’ll try to respond to all real life questions with a personal and prompt reply. Zoloft is a powerful antidepressant intended for short term use. WARNER, MAJ, MC, USA, Winn Army Community Hospital, Fort Stewart, Georgia WILLIAM BOBO, LCDR, MC, USN, Uniformed Services University of the Health Sciences, Bethesda, Maryland CAROLYNN WARNER, MAJ, MC, USA, Winn Army Community Hospital, Fort Stewart, Georgia SARA REID, CPT, USAF, MC, Bolling Air Force Base, Washington, D. JAMES RACHAL, MAJ, USAF, MC, Ehrling Berquist Air Force Hospital, Offutt Air Force Base, Omaha, Nebraska Am Fam Physician. Antidepressant discontinuation syndrome occurs in approximately 20 percent of patients after abrupt discontinuation of an antidepressant medication that was taken for at least six weeks. Typical symptoms of antidepressant discontinuation syndrome include flu-like symptoms, insomnia, nausea, imbalance, sensory disturbances, and hyperarousal. These symptoms usually are mild, last one to two weeks, and are rapidly extinguished with reinstitution of antidepressant medication. Antidepressant discontinuation syndrome is more likely with a longer duration of treatment and a shorter half-life of the treatment drug. A high index of suspicion should be maintained for the emergence of discontinuation symptoms, which should prompt close questioning regarding accidental or purposeful self-discontinuation of medication. Before antidepressants are prescribed, patient education should include warnings about the potential problems associated with abrupt discontinuation. Education about this common and likely underrecognized clinical phenomenon will help prevent future episodes and minimize the risk of misdiagnosis.
Antidepressants with longer half-lives, like Prozac and Zoloft, linger in the body for days. Withdrawal from these antidepressants lasts longer. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors SSRIs.